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Showing posts with label 0%. Show all posts

Friday, August 14, 2020

Vaccine for major common cold virus could be ready for use by 2024


right now it is the prime research target and it may well succeed. Certainly surprising paths have opened up, not least quinine to defeat cancers.

right now it is the heat of intensity driving us forward.

As noted, the common cold actually suppresses cancer and this has to be integrated as well..


Vaccine for major common cold virus could be ready for use by 2024



Respiratory syncytial virus particles (blue) in human lung cells


A vaccine that protects against one of the main common cold viruses has been shown to be safe and effective in a clinical trial and could be available by 2024.

Respiratory syncytial virus (RSV) is so contagious that more than 90 per cent of people have experienced their first infection by the age of 2. It usually causes cold symptoms but can lead to severe illness in young children and older people. Globally, around 60,000 children under the age of 5 and 14,000 people over the age of 65 die each year after contracting the virus.



Developing vaccines against RSV and other respiratory viruses has been challenging because the respiratory tract, which includes the nostrils and throat, is a surface exposed to the external rather than internal environment, says Kirsten Spann at the Queensland University of Technology in Australia, who wasn’t involved in the clinical trial.



“It’s harder for antiviral antibodies in the blood to reach viruses in the respiratory tract, or even know they are there, because there is some physical separation,” she says.

This also explains why we can get RSV and other cold viruses over and over again, says Spann.

In recent years, however, there has been rapid progress in finding new ways to boost immunity against respiratory viruses.

Several RSV vaccines are being tested in clinical trials, including one made by German company Bavarian Nordic. Its vaccine is designed to build immunity against RSV by exposing the body to five small fragments of the virus.

In a clinical trial involving 420 adults aged 55 and older, a single injection of the vaccine in the upper arm tripled the levels of RSV-fighting antibodies inside the nose and caused no serious side effects.

This immune response lasted for six months – enough to cover a winter cold season – and was restored with a booster shot at 12 months.



The results are promising, but more research is needed to see if the immune response is strong enough to prevent RSV infections, says Spann.

Bavarian Nordic is now planning a bigger clinical trial of its RSV vaccine that is scheduled to begin in 2021 and will involve more than 12,000 adults. If the results are positive, the company hopes to make the vaccine available by 2024. The firm plans to offer the vaccine to children too, but not until it has passed clinical trials involving people in this age range.

Vaccines for other cold viruses are also in development. US company Moderna, one of the leading covid-19 vaccine developers, is working on a vaccine to protect children against human metapneumovirus and parainfluenza viruses.

It is worth vaccinating against as many cold viruses as possible because infections in early life can increase the risk of developing asthma, says Spann.

Saturday, August 8, 2020

Soros Infuses $116K Into McCloskey Prosecutor’s PAC Days After Charges Filed


Yee!  Just when you thought criminal justice in the USA could not get worse, along comes george soros to demonstrate another angle.

The whole charade against the govenor was criminally inspired prosecution.  Skip any evidence and make it up as you go to gain the upper hand.  By the time process catches up you are past the goal posts and can change the rules.

Perhaps we shoiuld hang Mr Soros and dream up a charge next year to hang him with.  We are confronting true tyranny.






Soros Infuses $116K Into McCloskey Prosecutor’s PAC Days After Charges Filed



by 





Just eight days after St. Louis Circuit Attorney Kim Gardner filed charges against a wealthy couple who defended their home against trespassing protesters, George Soros donated $116,000 to a Political Action Committee (PAC) established for the activist prosecutor, according to JustTheNews.


A Saturday filing with the Missouri Ethics Commission revealed the donation made directly from Soros to the Missouri Justice and Public Safety PAC – for which Soros is the only donor so far. The PAC has already spent at least $104,393 – including $77,804 directly on Gardner, and a payoff of accumulated debt. Of note, Gardner has a primary this Tuesday.

Soros spokesman Michael Vachon told Just The News that Soros has made no secret that he supports prosecutors like Gardner for criminal justice reform.


Gardner slapped charges on personal injury lawyers Mark McCloskey, 63, and his wife Patricia, 61, who armed themselves and stood outside their mansion as a group of roughly 100 protesters broke down a gate to march down their private road.


For defending their property, the McCloskeys were each charged with a felony count of unlawful use of a weapon. Days after the charges were filed, it emerged that Gardner’s staff ordered a crime lab to tamper with evidence, by reassembling the ‘prop’ pistol Patricia was waving in order to make it “capable of lethal use.”

This isn’t the first brush with shoddy evidence for Gardner’s office;


Gardner, a Democrat, was elected in 2016 and supported by Soros-funded PACs, which financially back several prosecutors across America on a progressive criminal justice reform platform.


She drew national attention when she filed criminal charges against then-Republican Missouri Gov. Eric Greitens, forcing him to resign, only to reveal later she did not have evidence to substantiate her allegations. She is facing investigation for her conduct in the Greitens case, and her former chief investigator is awaiting trial on tampering charges.JustTheNews


Gardner’s decision to prosecute the McCloskeys ignited a controversy over Second Amendment rights, a well as Missouri’s “Castle Doctrine” which governs use of firearms to defend one’s home. Those defending the couple include President Trump, Missouri GOP Senator Josh Hawley, Missouri AG Eric Schmitt, and Gov. Michael Parson (R) who says he’ll pardon the McCloskeys.


Their attorney, Joel Schwartz, has filed a motion to dismiss both Gardner and her office from moving forward with their prosecution – claiming a conflict of interest, as “that Gardner’s campaign has used the McCloskeys’ incident to further her own financial, personal, and professional gain because Gardner sent out campaign solicitations for her re-election mentioning the McCloskeys,” according to the report.

Thursday, November 27, 2008

Aube Balten on Interest rates

For those who like their financial news grim, I am serving up a further dose of Aubie Baltin. He is worth supporting, if only to prevent one from ever getting too exuberant.

He is quite right about the direct consequences of low interest rates on the global financial system. It has promoted reckless lending simply because it gave the lenders no other choice other than exiting the business. This way they postponed it for about five years and now they are all gone. I remember wondering where the portfolio managers were getting their returns from with interest rates so low. We now know it was from thin air and based on the unreasonable proposition that a third of the population was going to double their incomes in a couple of years.

My own experience has informed me that when everything is working fine, bright young rookies are allowed free rein because they simply do not understand the limits. These guys go full out producing crummier and crummier product. They barely know better. And once the genie is out of the bottle, only a market downswing can end it, usually by busting the tyros.

The banks need to start lending and to accept that they must now charge their best clients perhaps six percent while forgetting about apparent unlimited access to cheap money. They need the real income because their real cost of money is no longer tied strictly to the nominal interest rate. It is tied to a ballooning loss rate that is certainly no longer 0.5% but likely closer to 3%. That means that even at zero interest for money that their cost of money is too high. Therefore, if they project a 3% loss ratio on their portfolios and place the funds at 6% they will be fine. At the portfolios improve, this cost structure will return to historic levels fairly quickly.

The mismanagement of the mortgage portfolio is already under control, except that they have yet to restructure the loans as per my suggestions. The overhang is so large that the underling real estate will continue to sink in value putting all mortgages underwater. The price drop in the USA was an astounding 20% this past quarter. This process is the equivalent of approaching every mortgage holder and effectively demanding immediate repayment.

We must set a mark to market day against which all mortgages can be automatically be restructured by the lenders.

Otherwise we will go to a price structure that taps only folks able to pay mostly cash.

The truth is that this is all pretty depressing to dwell on since ye and thee can do naught.

This crisis or collapse of confidence has exposed all the weak sisters for what they are and they will now be either fixed or rooted out. It is difficult and will require time.

Two things are happening or need to happen.

First of and well underway, the financial industry has had its capital replaced to make up present losses and thus permitting them to stay in the business of trying to fix their portfolios. All this money has already been lost into the economy over the past five years and cannot be recovered. It prevents fire sale liquidation of the banking industry as occurred in the, and was the real cause of the Great Depression. It is one thing for half the financial system to disappear into thin air, it is quite another for half the real economy to disappear as a direct result.

Second and not yet beginning we need a massive encouragement of investment in the energy business with guarantees and related contracts. This should include a massive switch over to electric cars ASAP. These will all repatriate cash flow into the domestic energy business. The Middle East needs to be put on notice that we are withdrawing from the oil business permanently.

If this were all happening, the USA balance of payments would quickly right itself and we would enter rapid growth. But as Aubie Balten laments, who is listening?



Dec 1st Issue

UNCOMMON COMMON SENSE
For People Who Think


THE PERILS OF PAULINE

THE DANGER AND PITFALLS OF LOW INTEREST RATES
The world, as well as all the experts, are witnessing in utter shock and disbelief the potential break down of the world’s financial system. They still can’t figure out why this is happening and therefore do not know what they should or could do about it.

UNINTENDED CONSEQUENCES are the main reason why free markets work and managed markets (Socialism) must eventually break down; nobody ever even thinks about the potential seemingly unrelated unintended consequences. Even if there were a few smart people who do think about such things, it is impossible to conjure up all the possible permutations and combinations that over time only a Free Market can factor in while giving the exact right amount of weight to each factor and come up with the exact right price and solutions.

ARTIFICALLY LOW (ZERO) INTEREST RATES

That’s enough of generalities; the main topic is ZERO interest rates and the unintended consequences of the FED maintaining artificially LOW interest rates. On numerous occasions, I have pointed out and explained the functions of interest rates, such as determining the marginal propensity to consume vs. save. and the most efficient allocation of scarce savings among investment projects. But theses are well known factors even though they have been ignored and are the main causes behind the business cycle.

LEVERAGE has become the main unintended consequence of artificially low interest rates. With a real inflation rate of 3% and yield spread of only 2%, it is impossible for Banks to make money and therefore no lending will take place unless a way could be found to increase the rate of return on their capital: Low and behold, LEVERAGE was discovered. If you could leverage your capital at 10 to 1, a 1% profit becomes a 10% profit. At 40 to 1, 1% becomes 40% and at a 100 to 1 you double your money every year. Not to bad, AY? But alas, there is a catch; leverage is a two edged sword. A 1% loss on a 100 to 1 leverage wipes out your capital completely. Among the first highly leveraged deals was the carry trade; buying US Treasuries with borrowed Yen. And what a deal that turned out to be. Initially, not only did they make money on the interest rate spread but they made even more as the Dollar began increasing 5% to 8% a year against the Yen. This gave rise to the Hedge Fund Industry as they convinced everyone how smart they were. Of course they did not warn anyone about the risks involved or of the possibility that the Yen would reverse and go up against all currencies. Therefore the only safe thing to do was to move the business offshore, limiting the investors to exempt investors and institutions: Low and behold, no Government rules or oversight and no SEC approved audited prospectus requirement: After all, exempt individuals and institutions are supposed to be smart enough to protect themselves, right? Too bad they had to ignore all the little suckers but never mind, there were enough rich suckers with a lot more money to go around. What they never expected was that after a few years of 40%+ returns, the biggest suckers of all, the major Pension and Endowment Funds, after 10 years of no gain in stocks, would jump into the quicksand with both feet.. PARADISE FOUND.

There is always an element of self preservation at work at all times and now that they had found a license to print money, they looked for a way to both increase their leverage and more importantly, protect themselves against risks. Low and behold, Credit Default Swaps (CDS) and other insurance derivatives against other types of risks (interest rates, currency, etc.) were invented, which allowed leverage to be increased to unimagined levels. But it didn’t stop there. Whatever the Market was looking for Wall St. created. The one thing Pension, Insurance and other big Investors were looking for was AAA Bonds that paid a high enough rate of return (since Treasuries were no longer paying enough) to allow them to stay in business without taking undue risk. Sure enough, the experts on Wall St. provided that using sub-prime mortgages packaged and repackaged using CDS’S as they coerced the credit rating agencies into give them AAA ratings on junk sub-prime MBS’S and they were snapped up like crazy. The real professionals knew that the stock market was way overpriced and all they wanted was a reasonable 5% to 7% return on AAA no risk Bonds. Ask and you shall receive. Wall St. couldn’t package them fast enough. But they should have known better because any time you are offered something that is too good to be true, it usually is not true, especially not in the volumes that were involved. They were making so much money that Wall St. began to believe their own B.S. and so when Yen started to appreciate and the carry trade was no longer so hot they loaded up on their own junk. After all they had to put their ill gotten gains somewhere. Everything was going fine as long as the real estate market, the ultimate insurer, that was backing all this pie in the sky, was appreciating at a compound annual rate of 15% to 25% plus. But alas, all good things must come to an end as reality eventually sets in and all bubbles and Ponzi schemes must also eventually blow-up.

We are now living through and witnessing what happens when government interferes with the free markets and no matter how good the intentions, their inability to identify all of the unintended consequences of artificially low interest rates, came back to bite us all in the neck.

WONDER OF WONDERS

It is hard for me to understand why Economists (left & Right) still want to continue doing what got them into trouble in the first place. Hasn’t the last 20 years of Japan’s, zero interest rate, recession, taught them anything?

As far back as 2004, I began writing essay after essay, trying to explain what the functions of interest rates are and how they worked, but nobody was listening and nobody took any interest. In letter after letter there was often a paragraph that pointed out the perils of excessively low interest rates. What about the savers I screamed as the nation’s saving rate dropped from a high of 15% to zero and then -1%? What about the retired seniors who had their life savings in12% and 15% CD’S and Treasuries that were now maturing and could only be replaced with 3% or 4% CD”S - how will they be able to pay their bills?. Let them buy Stock Mutual Funds that have returned an average of 8% over the last 75 years (the BIG lie). Besides, what are they complaining about? We just gave them free prescription drugs didn’t we? But who cared, the party was a blast and the champagne (money) was flowing like water. Besides, who wants to listen to a kill-joy when you’re having fun? Unfortunately, even the best of parties must come to an end as the sun always rises and every party must be paid for by someone. The bigger the party, the bigger the bill. This party was so big that the whole world will end up paying a far higher price than anyone could possibly have imagined. (say unintended consequences?)

If history is any guide, World War III is near at hand. GOD I hope I’m wrong this time.

GOLD

They've been dumping Gold for a couple of reasons: 1) prices are falling; 2) credit lines are either being pulled back or completely taken away. 3) In many cases, investors have no choice but to liquidate their gold positions as they are their only positions that have a decent bid and or are their only positions in which they are still showing a profit. ( Great Idea; cut your profits short, so you can pay taxes on them, while letting your losses run; Is that how its supposed to go?)

During the heyday of the commodity bubble, I cautioned all investors that there would be a major supply response to continued high prices. The Laws of Supply and Demand may be asleep but they are not Dead.
What could keep Gold prices down?

You would really have to get back to a place where the economic, political and financial situations are no longer worrisome ... before you see people sell gold and jump back into stock and bonds. That's the only likely scenario for lower gold prices that I can come up with In the gold mining equity market or any other mining market, even Oil and Gas, you saw that the price of the equities were pushed much higher by the momentum players (hedge Funds) than what could be considered a reasonable value. Now, the prices of a lot of equities are far below what you could consider a reasonable value for the enterprise. The rules of the game never changes but they do masquerade in an attempt to fool the majority; the lazy and the gullible: It’s the way the world works, I guess.

WHERE TO NOW DOW?

If you can recall my Jan. 2008 article “GOLD AND A KONDRIETIFF WINTER” If you can’t then I strongly suggest you go back in to my archives and read it again. By the S & P breaking down below its 2002 Bear Market lows; we now have confirmation that we are in multi-generational Bear Market of Grand Super-cycle proportions. If it is to be only a Wave {IV} down, correcting Wave {III} of the Bull Market that began in the mid 1700’s as Prechter, Hughs and some other well know Elliott Wave Theoreticians, believe and not the fifth and final WAVE {5} then the good news is “The World is Not Coming To an End” The BAD NEWS is that we will most likely see significant NEW lows that will probably go much lower than Thursdays lows (maybe as low as DJII 4000) before this Bear Market is over. We have only seen the first wave (Wave A) of the Tsunami and the devastating second Wave (Wave C) is yet to come. Luckily things are not all bad and the good news is we are about to enter a period of relative calm, Wave B of the Forth Wave {which is usually an a,b,c,d,e, Diagonal Triangle; with the a wave being the longest} is often only a sideways type phase- to this three phase Bear market. This Grand Super-cycle wave {IV} down is correcting centuries of Bull Markets and it will seem fast, and furious. But time-wise, it may be relatively short compared to other Grand Super-cycle waves, but damage-wise, this Bear Market could change the world. The next 4 years and the election of 2012 could be the most important election since 1776 as it will determine whether we regress into the Demagoguery of Communism - Fascism or explode into a new era of FREEDOM.

HAS THE BOTTOM BEEN MADE?.
We are at or near the end of the first phase; Wave {A} down. That bottom is imminent. In fact it may have been made Thursday, November 20th, 2008, Or, it may need one more declining wave to complete this wave {A} down move from October 2007, a Super-cycle wave that has wiped out a decade of stock market gains, over 50 percent of the market's value, in just one year!

Wave {B} up which may have started Friday, November 21st, or will within a week or so ( I will be able to get a better picture once I am sure that the Wave {A} bottom has been made)

.WARNING DO NOT CHASE A 1000 POINT BOUNCE:

Wave {B} up is a gift. It is for short term Traders only use it to BUILD YOUR CASH POSITIONS AND GET OUT OF DEBT. It is like the eye of a level 5 hurricane. Your last chance to raise cash at higher prices. Because, once it completes, the devastating plunge will resume and take prices far lower than anyone - even Bears can - now imagine, wave C’s down behave like Wave 3’s, They are usually the longest and strongest of the waves and therefore Wave {B‘s} are the best time to accumulate GOLD.
The Industrials are down 2,204 points, or 22.8 percent since Election Day. The S&P 500 is down 266 points, or 26.5 percent since Election Day.

What bothers me is that Thursday did not see a DJII closing low below the Bear Market low of 2002. But since Friday closed 5 percent higher, I cannot rule out a bottom but I am still a bit hesitant in calling a bottom because (a) my Elliott wave Declining pattern does not look complete and (b) the 10 day average Advance/Decline Line Indicator actually got worse Friday for both the S&P 500 and for the NDX, on a day when prices rose 5 percent. That is odd for the start of a rally phase after such a strong sell-off - Call it a minor Bearish Divergence. (c) New Lows were also way too high again on Friday, (d) 47 percent of total issues traded on the NYSE were down. And Advances were only 63 percent of total issues traded. The start of major rally phases normally do better than that. We also did not get a 90 percent up day Friday, which is something I would like to see at the start of a major rally. And finally Friday was options expiration day which is usually a rally day, anyway: And last but far from least The rally according to all the media talking heads was tied to the big news that Obama is tapping the popular New York Fed's President to be the next Secretary of the Treasury in 2010, really?. Rallies on news often can't really be trusted, especially when the big new is really no news at all.

THANKSGIVING DAY SPECIAL
I am offering a Special two year subscription for only $339. The one year subscription is still a reasonable $199 until the end of the year at which time prices will increase to $269.00 and $469: Extend your subscription Now “PROCRASTINATION IS THE THIEF OF LIFE”

If you have been enjoying these letters and have found them to be useful please tell your friends

HAPPY THANKSGIVING GOOD LUCK AND GOD BLESS


UNCOMMON COMMON SENSE November 24, 2008
Aubie Baltin CFA, CTA, CFP, PhD.
2078 Bonisle Circle
Palm Beach Gardens FL. 33418
aubiebat@yahoo.com
561-840-9767

Please Note: This article is for education purposes only and is designed to help you make up your own mind, not for me to make it up for you. Only you know your own personal circumstances so only you can decide the best places to invest your money and the degree of risk that you are prepared to take. The Information on data included here has been gleaned from sources deemed to be reliable, but is not guaranteed by me. Nothing stated in here should be taken as a recommendation for you to buy or sell securities.